{"id":165,"title":"Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse","short_name":"Antiestrogens and ovarian adenomas/granular cell tumors","created_at":"2016-11-29T18:41:17.000-05:00","updated_at":"2023-09-25T16:26:53.000-04:00","corresponding_author":{"id":17710,"created_at":"2023-09-11T18:10:58.000-04:00","updated_at":"2023-09-11T18:10:58.000-04:00","subscribed":true,"novice":null},"aop_stressors":[{"stressor_id":172,"stressor_name":"Tamoxifen"},{"stressor_id":173,"stressor_name":"Raloxifene"},{"stressor_id":174,"stressor_name":"Fulvestrant"}],"aop_mies":[],"aop_kes":[{"event_id":1045,"event":"Decreased, Ovarian E2","event_type":"KeyEvent"},{"event_id":1046,"event":"Suppression, Estrogen receptor (ER) activity","event_type":"KeyEvent"},{"event_id":1047,"event":"Increased, secretion of GnRH from hypothalamus","event_type":"KeyEvent"},{"event_id":1049,"event":"Increased, secrection of FSH from anterior pituitary","event_type":"KeyEvent"},{"event_id":1050,"event":"Increased, secretion of LH from anterior pituitary","event_type":"KeyEvent"},{"event_id":1051,"event":"Hyperplasia, ovarian stromal cells","event_type":"KeyEvent"},{"event_id":1052,"event":"Hyperplasia, ovarian epithelium","event_type":"KeyEvent"},{"event_id":1056,"event":"Decrease, E2 blood concentrations at hypothalamus","event_type":"KeyEvent"}],"aop_aos":[{"event_id":1053,"event":"Promotion, ovarian adenomas","event_type":"AdverseOutcome"},{"event_id":1054,"event":"Promotion, ovarian granular cell tumors","event_type":"AdverseOutcome"}],"relationships":[{"relation":750,"upstream_event_id":1045,"upstream_event":"Decreased, Ovarian E2","downstream_event_id":1056,"downstream_event":"Decrease, E2 blood concentrations at hypothalamus"},{"relation":751,"upstream_event_id":1046,"upstream_event":"Suppression, Estrogen receptor (ER) activity","downstream_event_id":1056,"downstream_event":"Decrease, E2 blood concentrations at hypothalamus"},{"relation":752,"upstream_event_id":1056,"upstream_event":"Decrease, E2 blood concentrations at hypothalamus","downstream_event_id":1047,"downstream_event":"Increased, secretion of GnRH from hypothalamus"},{"relation":753,"upstream_event_id":1047,"upstream_event":"Increased, secretion of GnRH from hypothalamus","downstream_event_id":1049,"downstream_event":"Increased, secrection of FSH from anterior pituitary"},{"relation":754,"upstream_event_id":1047,"upstream_event":"Increased, secretion of GnRH from hypothalamus","downstream_event_id":1050,"downstream_event":"Increased, secretion of LH from anterior pituitary"},{"relation":755,"upstream_event_id":1049,"upstream_event":"Increased, secrection of FSH from anterior pituitary","downstream_event_id":1051,"downstream_event":"Hyperplasia, ovarian stromal cells"},{"relation":756,"upstream_event_id":1049,"upstream_event":"Increased, secrection of FSH from anterior pituitary","downstream_event_id":1052,"downstream_event":"Hyperplasia, ovarian epithelium"},{"relation":757,"upstream_event_id":1050,"upstream_event":"Increased, secretion of LH from anterior pituitary","downstream_event_id":1051,"downstream_event":"Hyperplasia, ovarian stromal cells"},{"relation":758,"upstream_event_id":1052,"upstream_event":"Hyperplasia, ovarian epithelium","downstream_event_id":1053,"downstream_event":"Promotion, ovarian adenomas"},{"relation":759,"upstream_event_id":1051,"upstream_event":"Hyperplasia, ovarian stromal cells","downstream_event_id":1054,"downstream_event":"Promotion, ovarian granular cell tumors"}]}