PR:000001193 PR beta-2 adrenergic receptor CL:0000192 CL smooth muscle cell UBERON:0001135 UBERON smooth muscle tissue D007889 MESH leiomyoma GO:0031698 GO beta-2 adrenergic receptor binding GO:0004941 GO beta2-adrenergic receptor activity GO:0044557 GO relaxation of smooth muscle GO:0008283 GO cell proliferation D006984 MESH hypertrophy 1 WIKI increased 10090 NCBI CD-1 mouse 10116 NCBI SD rat Activation, beta-2 adrenergic receptor Molecular CL:0000255 CL eukaryotic cell AOPWiki 2016-11-29T18:41:28 2017-09-16T10:17:04 Increased activity, beta-2 adrenergic receptor Molecular CL:0000255 CL eukaryotic cell AOPWiki 2016-11-29T18:41:28 2017-09-16T10:17:04 relaxation, smooth muscle Tissue AOPWiki 2016-11-29T18:41:28 2016-12-03T16:37:52 Proliferation/Clonal Expansion, smooth muscle Cellular CL:0000192 CL smooth muscle cell AOPWiki 2016-11-29T18:41:28 2017-09-16T10:17:04 Hypertrophy/hyperplasia, smooth muscle Cellular AOPWiki 2016-11-29T18:41:28 2016-12-03T16:37:52 Promotion, mesovarian leiomyomas Tissue UBERON:0000995 UBERON uterus AOPWiki 2016-11-29T18:41:28 2017-09-16T10:17:05 #<Reference::ActiveRecord_Associations_CollectionProxy:0x00007b42e9d87668> AOPWiki 2016-11-29T18:41:36 2016-12-03T16:38:03 #<Reference::ActiveRecord_Associations_CollectionProxy:0x00007b42e9d998b8> AOPWiki 2016-11-29T18:41:36 2016-12-03T16:38:03 #<Reference::ActiveRecord_Associations_CollectionProxy:0x00007b42e9dc14f8> AOPWiki 2016-11-29T18:41:36 2016-12-03T16:38:03 #<Reference::ActiveRecord_Associations_CollectionProxy:0x00007b42e9de8f80> AOPWiki 2016-11-29T18:41:36 2016-12-03T16:38:03 #<Reference::ActiveRecord_Associations_CollectionProxy:0x00007b42e9e19360> AOPWiki 2016-11-29T18:41:36 2016-12-03T16:38:03 Beta-2 adrenergic agonist induction of mesovarian leiomyomas Allie Always <p>Cancer AOP Workgroup. National Health and Environmental Effects Research Laboratory, Office of Research and Development, Integrated Systems Toxicology Division, US Environmental Protection Agency, Research Triangle Park, NC. Corresponding author for wiki entry (wood.charles@epa.gov)</p> BY-SA 1.29 1.0 <p>This putative adverse outcome pathway (AOP) outlines potential key events leading to a tumor outcome in standard carcinogenicity models. This information is based largely on modes of action described previously in cited literature sources and is intended as a resource template for AOP development and data organization. Presentation in this Wiki does not indicate EPA acceptance of a particular pathway for a given reference agent, only that the information has been proposed in some manner. In addition, this putative AOP relates to the model species indicated and does not directly address issues of human relevance.</p> adjacent Not Specified High adjacent Not Specified High adjacent Not Specified High non-adjacent Not Specified High non-adjacent Not Specified High High Female High High <p>1. Gibson, J. P., Sells, D. M., Cheng, H. C., and Yuh, L. (1987). Induction of uterine leiomyomas in mice by medroxalol and prevention by propranolol. Toxicologic pathology 15(4), 468-73.</p> <p>2. Gopinath, C., and Gibson, W. A. (1987). Mesovarian leiomyomas in the rat. Environmental health perspectives 73, 107-13.</p> <p>&nbsp;</p> AOPWiki 2016-11-29T18:41:17 2023-09-25T16:26:53