{"id":164,"title":"Beta-2 adrenergic agonist activity leading to mesovarian leiomyomas in the rat and mouse","short_name":"Beta-2 adrenergic agonist induction of mesovarian leiomyomas","created_at":"2016-11-29T18:41:17.000-05:00","updated_at":"2023-09-25T16:26:53.000-04:00","corresponding_author":{"id":17717,"created_at":"2023-09-11T18:10:59.000-04:00","updated_at":"2023-09-12T12:20:02.000-04:00","subscribed":true,"novice":null},"aop_stressors":[],"aop_mies":[{"event_id":1038,"event":"Activation, beta-2 adrenergic receptor","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1039,"event":"Increased activity, beta-2 adrenergic receptor","event_type":"KeyEvent"},{"event_id":1040,"event":"relaxation, smooth muscle","event_type":"KeyEvent"},{"event_id":1042,"event":"Proliferation/Clonal Expansion, smooth muscle","event_type":"KeyEvent"},{"event_id":1043,"event":"Hypertrophy/hyperplasia, smooth muscle","event_type":"KeyEvent"}],"aop_aos":[{"event_id":1044,"event":"Promotion, mesovarian leiomyomas","event_type":"AdverseOutcome"}],"relationships":[{"relation":745,"upstream_event_id":1038,"upstream_event":"Activation, beta-2 adrenergic receptor","downstream_event_id":1039,"downstream_event":"Increased activity, beta-2 adrenergic receptor"},{"relation":746,"upstream_event_id":1039,"upstream_event":"Increased activity, beta-2 adrenergic receptor","downstream_event_id":1040,"downstream_event":"relaxation, smooth muscle"},{"relation":747,"upstream_event_id":1040,"upstream_event":"relaxation, smooth muscle","downstream_event_id":1042,"downstream_event":"Proliferation/Clonal Expansion, smooth muscle"},{"relation":748,"upstream_event_id":1042,"upstream_event":"Proliferation/Clonal Expansion, smooth muscle","downstream_event_id":1043,"downstream_event":"Hypertrophy/hyperplasia, smooth muscle"},{"relation":749,"upstream_event_id":1043,"upstream_event":"Hypertrophy/hyperplasia, smooth muscle","downstream_event_id":1044,"downstream_event":"Promotion, mesovarian leiomyomas"}]}