{"id":163,"title":"PPARgamma activation leading to sarcomas in rats, mice, and hamsters","short_name":"PPARgamma-related sarcomas","created_at":"2016-11-29T18:41:17.000-05:00","updated_at":"2023-09-25T16:26:52.000-04:00","corresponding_author":{"id":17716,"created_at":"2023-09-11T18:10:59.000-04:00","updated_at":"2023-11-28T16:27:24.000-05:00","subscribed":true,"novice":null},"aop_stressors":[{"stressor_id":70,"stressor_name":"Troglitazone"}],"aop_mies":[{"event_id":1028,"event":"Activation of specific nuclear receptors, PPAR-gamma activation","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1029,"event":"Increased, adipogenesis","event_type":"KeyEvent"},{"event_id":1032,"event":"Increased, secretion of local growth factors","event_type":"KeyEvent"},{"event_id":1033,"event":"Increased, proliferation of mesenchymal cells","event_type":"KeyEvent"},{"event_id":1034,"event":"Increased, IGF-1 (mouse)","event_type":"KeyEvent"},{"event_id":1035,"event":"Increased, Firbrosarcoma","event_type":"KeyEvent"},{"event_id":1036,"event":"Increased, liposarcoma","event_type":"KeyEvent"},{"event_id":1037,"event":"Increased, hemagiosarcoma","event_type":"KeyEvent"}],"aop_aos":[],"relationships":[{"relation":737,"upstream_event_id":1028,"upstream_event":"Activation of specific nuclear receptors, PPAR-gamma activation","downstream_event_id":1029,"downstream_event":"Increased, adipogenesis"},{"relation":738,"upstream_event_id":1028,"upstream_event":"Activation of specific nuclear receptors, PPAR-gamma activation","downstream_event_id":1032,"downstream_event":"Increased, secretion of local growth factors"},{"relation":739,"upstream_event_id":1029,"upstream_event":"Increased, adipogenesis","downstream_event_id":1032,"downstream_event":"Increased, secretion of local growth factors"},{"relation":740,"upstream_event_id":1032,"upstream_event":"Increased, secretion of local growth factors","downstream_event_id":1033,"downstream_event":"Increased, proliferation of mesenchymal cells"},{"relation":741,"upstream_event_id":1032,"upstream_event":"Increased, secretion of local growth factors","downstream_event_id":1034,"downstream_event":"Increased, IGF-1 (mouse)"},{"relation":742,"upstream_event_id":1033,"upstream_event":"Increased, proliferation of mesenchymal cells","downstream_event_id":1035,"downstream_event":"Increased, Firbrosarcoma"},{"relation":743,"upstream_event_id":1033,"upstream_event":"Increased, proliferation of mesenchymal cells","downstream_event_id":1036,"downstream_event":"Increased, liposarcoma"},{"relation":744,"upstream_event_id":1033,"upstream_event":"Increased, proliferation of mesenchymal cells","downstream_event_id":1037,"downstream_event":"Increased, hemagiosarcoma"}]}