{"id":162,"title":"Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse","short_name":"thyroid follicular cell adenomas and carcinomas","created_at":"2016-11-29T18:41:17.000-05:00","updated_at":"2023-09-25T16:26:52.000-04:00","corresponding_author":{"id":17713,"created_at":"2023-09-11T18:10:58.000-04:00","updated_at":"2023-12-20T10:05:07.000-05:00","subscribed":true,"novice":null},"aop_stressors":[{"stressor_id":133,"stressor_name":"Phenobarbital"},{"stressor_id":170,"stressor_name":"thiazopyr"},{"stressor_id":171,"stressor_name":"Pyrethrins and Pyrethroids"}],"aop_mies":[],"aop_kes":[{"event_id":295,"event":"Induction, Upregulation of glucuronyltransferase activity","event_type":"KeyEvent"},{"event_id":961,"event":"Increased, Clearance of thyroxine from serum","event_type":"KeyEvent"},{"event_id":281,"event":" Thyroxine (T4) in serum, Decreased","event_type":"KeyEvent"},{"event_id":1023,"event":"Increased, Thyroid-stimulating hormone (TSH)","event_type":"KeyEvent"},{"event_id":739,"event":"Increase, Hypertrophy and proliferation (follicular cell)","event_type":"KeyEvent"},{"event_id":740,"event":"Increase, Hyperplasia (follicular cells)","event_type":"KeyEvent"}],"aop_aos":[{"event_id":741,"event":"Increase, Adenomas/carcinomas (follicular cell)","event_type":"AdverseOutcome"}],"relationships":[{"relation":2826,"upstream_event_id":295,"upstream_event":"Induction, Upregulation of glucuronyltransferase activity","downstream_event_id":961,"downstream_event":"Increased, Clearance of thyroxine from serum"},{"relation":2827,"upstream_event_id":961,"upstream_event":"Increased, Clearance of thyroxine from serum","downstream_event_id":281,"downstream_event":" Thyroxine (T4) in serum, Decreased"},{"relation":2741,"upstream_event_id":281,"upstream_event":" Thyroxine (T4) in serum, Decreased","downstream_event_id":1023,"downstream_event":"Increased, Thyroid-stimulating hormone (TSH)"},{"relation":2752,"upstream_event_id":1023,"upstream_event":"Increased, Thyroid-stimulating hormone (TSH)","downstream_event_id":739,"downstream_event":"Increase, Hypertrophy and proliferation (follicular cell)"},{"relation":2753,"upstream_event_id":739,"upstream_event":"Increase, Hypertrophy and proliferation (follicular cell)","downstream_event_id":740,"downstream_event":"Increase, Hyperplasia (follicular cells)"},{"relation":2751,"upstream_event_id":740,"upstream_event":"Increase, Hyperplasia (follicular cells)","downstream_event_id":741,"downstream_event":"Increase, Adenomas/carcinomas (follicular cell)"}]}