{"id":160,"title":"Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality","short_name":"iGABAR activation leading to mortality","created_at":"2016-11-29T18:41:17.000-05:00","updated_at":"2023-09-25T16:26:52.000-04:00","corresponding_author":{"id":17711,"created_at":"2023-09-11T18:10:58.000-04:00","updated_at":"2023-09-11T18:10:58.000-04:00","subscribed":true,"novice":null},"aop_stressors":[{"stressor_id":83,"stressor_name":"Emamectin benzoate"}],"aop_mies":[{"event_id":762,"event":"Activation, ionotropic GABA Receptor chloride channel","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1012,"event":"Increased, Inhibitory postsynaptic potential","event_type":"KeyEvent"},{"event_id":1014,"event":"Induction, Somatic muscle paralysis","event_type":"KeyEvent"},{"event_id":761,"event":"Increased, Chloride conductance","event_type":"KeyEvent"},{"event_id":1015,"event":"Increased, Neuronal synaptic inhibition","event_type":"KeyEvent"},{"event_id":1016,"event":"Inhibition, Feeding","event_type":"KeyEvent"}],"aop_aos":[{"event_id":351,"event":"Increased Mortality","event_type":"AdverseOutcome"}],"relationships":[{"relation":711,"upstream_event_id":1014,"upstream_event":"Induction, Somatic muscle paralysis","downstream_event_id":351,"downstream_event":"Increased Mortality"},{"relation":712,"upstream_event_id":762,"upstream_event":"Activation, ionotropic GABA Receptor chloride channel","downstream_event_id":761,"downstream_event":"Increased, Chloride conductance"},{"relation":713,"upstream_event_id":761,"upstream_event":"Increased, Chloride conductance","downstream_event_id":1015,"downstream_event":"Increased, Neuronal synaptic inhibition"},{"relation":714,"upstream_event_id":1015,"upstream_event":"Increased, Neuronal synaptic inhibition","downstream_event_id":1012,"downstream_event":"Increased, Inhibitory postsynaptic potential"},{"relation":715,"upstream_event_id":1012,"upstream_event":"Increased, Inhibitory postsynaptic potential","downstream_event_id":1014,"downstream_event":"Induction, Somatic muscle paralysis"},{"relation":716,"upstream_event_id":1014,"upstream_event":"Induction, Somatic muscle paralysis","downstream_event_id":1016,"downstream_event":"Inhibition, Feeding"},{"relation":717,"upstream_event_id":1016,"upstream_event":"Inhibition, Feeding","downstream_event_id":351,"downstream_event":"Increased Mortality"}]}