{"id":152,"title":"Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity ","short_name":"Transthyretin interference","created_at":"2016-11-29T18:41:17.000-05:00","updated_at":"2023-09-25T16:26:52.000-04:00","corresponding_author":{"id":17717,"created_at":"2023-09-11T18:10:59.000-04:00","updated_at":"2023-09-12T12:20:02.000-04:00","subscribed":true,"novice":null},"aop_stressors":[{"stressor_id":160,"stressor_name":"Halogenated phenols"},{"stressor_id":148,"stressor_name":"Polychlorinated biphenyl"},{"stressor_id":256,"stressor_name":"Polychlorinated dibenzodioxins"},{"stressor_id":257,"stressor_name":"Polybrominated diphenyl ethers"},{"stressor_id":258,"stressor_name":"Isoflavones"},{"stressor_id":259,"stressor_name":"Perflourinated chemicals"},{"stressor_id":260,"stressor_name":"Phthalates"},{"stressor_id":261,"stressor_name":"Tetrabromobisphenol A"},{"stressor_id":262,"stressor_name":"Clonixin"},{"stressor_id":263,"stressor_name":"Meclofenamic acid"},{"stressor_id":264,"stressor_name":"2,6-dinitro-p-cresol"},{"stressor_id":265,"stressor_name":"Triclopyr"},{"stressor_id":74,"stressor_name":"2,2',4,4'-Tetrahydroxybenzophenone"}],"aop_mies":[{"event_id":957,"event":"Binding, Transthyretin in serum","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":958,"event":"Displacement, Serum thyroxine (T4) from transthyretin","event_type":"KeyEvent"},{"event_id":959,"event":"Increased, Free serum thyroxine (T4)","event_type":"KeyEvent"},{"event_id":960,"event":"Increased, Uptake of thyroxine into tissue","event_type":"KeyEvent"},{"event_id":961,"event":"Increased, Clearance of thyroxine from serum","event_type":"KeyEvent"},{"event_id":281,"event":" Thyroxine (T4) in serum, Decreased","event_type":"KeyEvent"},{"event_id":280,"event":"Thyroxine (T4) in neuronal tissue, Decreased ","event_type":"KeyEvent"},{"event_id":756,"event":"Hippocampal gene expression, Altered ","event_type":"KeyEvent"},{"event_id":757,"event":"Hippocampal anatomy, Altered ","event_type":"KeyEvent"},{"event_id":758,"event":"Hippocampal Physiology, Altered","event_type":"KeyEvent"}],"aop_aos":[{"event_id":402,"event":"Cognitive Function, Decreased ","event_type":"AdverseOutcome"}],"relationships":[{"relation":2491,"upstream_event_id":957,"upstream_event":"Binding, Transthyretin in serum","downstream_event_id":958,"downstream_event":"Displacement, Serum thyroxine (T4) from transthyretin"},{"relation":2498,"upstream_event_id":958,"upstream_event":"Displacement, Serum thyroxine (T4) from transthyretin","downstream_event_id":959,"downstream_event":"Increased, Free serum thyroxine (T4)"},{"relation":2497,"upstream_event_id":959,"upstream_event":"Increased, Free serum thyroxine (T4)","downstream_event_id":961,"downstream_event":"Increased, Clearance of thyroxine from serum"},{"relation":2495,"upstream_event_id":961,"upstream_event":"Increased, Clearance of thyroxine from serum","downstream_event_id":281,"downstream_event":" Thyroxine (T4) in serum, Decreased"}]}