{"id":134,"title":"Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals","short_name":"NIS and Cognitive Dysfunction","created_at":"2016-11-29T18:41:16.000-05:00","updated_at":"2023-09-25T16:26:51.000-04:00","corresponding_author":{"id":17710,"created_at":"2023-09-11T18:10:58.000-04:00","updated_at":"2023-09-11T18:10:58.000-04:00","subscribed":true,"novice":null},"aop_stressors":[],"aop_mies":[{"event_id":424,"event":"Inhibition, Na+/I- symporter (NIS)","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":277,"event":"Thyroid hormone synthesis, Decreased","event_type":"KeyEvent"},{"event_id":425,"event":"Decrease of Thyroidal iodide","event_type":"KeyEvent"},{"event_id":281,"event":" Thyroxine (T4) in serum, Decreased","event_type":"KeyEvent"},{"event_id":280,"event":"Thyroxine (T4) in neuronal tissue, Decreased ","event_type":"KeyEvent"},{"event_id":756,"event":"Hippocampal gene expression, Altered ","event_type":"KeyEvent"},{"event_id":757,"event":"Hippocampal anatomy, Altered ","event_type":"KeyEvent"},{"event_id":758,"event":"Hippocampal Physiology, Altered","event_type":"KeyEvent"}],"aop_aos":[{"event_id":402,"event":"Cognitive Function, Decreased ","event_type":"AdverseOutcome"}],"relationships":[{"relation":550,"upstream_event_id":424,"upstream_event":"Inhibition, Na+/I- symporter (NIS)","downstream_event_id":425,"downstream_event":"Decrease of Thyroidal iodide"},{"relation":551,"upstream_event_id":425,"upstream_event":"Decrease of Thyroidal iodide","downstream_event_id":277,"downstream_event":"Thyroid hormone synthesis, Decreased"},{"relation":552,"upstream_event_id":277,"upstream_event":"Thyroid hormone synthesis, Decreased","downstream_event_id":281,"downstream_event":" Thyroxine (T4) in serum, Decreased"},{"relation":553,"upstream_event_id":281,"upstream_event":" Thyroxine (T4) in serum, Decreased","downstream_event_id":280,"downstream_event":"Thyroxine (T4) in neuronal tissue, Decreased "},{"relation":554,"upstream_event_id":280,"upstream_event":"Thyroxine (T4) in neuronal tissue, Decreased ","downstream_event_id":756,"downstream_event":"Hippocampal gene expression, Altered "},{"relation":555,"upstream_event_id":756,"upstream_event":"Hippocampal gene expression, Altered ","downstream_event_id":757,"downstream_event":"Hippocampal anatomy, Altered "},{"relation":556,"upstream_event_id":757,"upstream_event":"Hippocampal anatomy, Altered ","downstream_event_id":758,"downstream_event":"Hippocampal Physiology, Altered"},{"relation":557,"upstream_event_id":758,"upstream_event":"Hippocampal Physiology, Altered","downstream_event_id":402,"downstream_event":"Cognitive Function, Decreased "},{"relation":558,"upstream_event_id":281,"upstream_event":" Thyroxine (T4) in serum, Decreased","downstream_event_id":402,"downstream_event":"Cognitive Function, Decreased "}]}