{"id":131,"title":"Aryl hydrocarbon receptor activation leading to uroporphyria","short_name":"AHR activation-uroporphyria","created_at":"2016-11-29T18:41:16.000-05:00","updated_at":"2023-09-25T16:26:51.000-04:00","corresponding_author":{"id":17717,"created_at":"2023-09-11T18:10:59.000-04:00","updated_at":"2023-09-12T12:20:02.000-04:00","subscribed":true,"novice":null},"aop_stressors":[{"stressor_id":147,"stressor_name":"Dibenzo-p-dioxin"},{"stressor_id":148,"stressor_name":"Polychlorinated biphenyl"},{"stressor_id":150,"stressor_name":"Hexachlorobenzene"},{"stressor_id":250,"stressor_name":"Polycyclic aromatic hydrocarbons (PAHs)"}],"aop_mies":[{"event_id":18,"event":"Activation, AhR","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":850,"event":"Induction, CYP1A2/CYP1A5","event_type":"KeyEvent"},{"event_id":844,"event":"Oxidation, Uroporphyrinogen","event_type":"KeyEvent"},{"event_id":845,"event":"Inhibition, UROD","event_type":"KeyEvent"},{"event_id":846,"event":"Accumulation, Highly carboxylated porphyrins","event_type":"KeyEvent"}],"aop_aos":[{"event_id":369,"event":"Uroporphyria","event_type":"AdverseOutcome"}],"relationships":[{"relation":599,"upstream_event_id":18,"upstream_event":"Activation, AhR","downstream_event_id":850,"downstream_event":"Induction, CYP1A2/CYP1A5"},{"relation":544,"upstream_event_id":850,"upstream_event":"Induction, CYP1A2/CYP1A5","downstream_event_id":844,"downstream_event":"Oxidation, Uroporphyrinogen"},{"relation":801,"upstream_event_id":844,"upstream_event":"Oxidation, Uroporphyrinogen","downstream_event_id":845,"downstream_event":"Inhibition, UROD"},{"relation":802,"upstream_event_id":845,"upstream_event":"Inhibition, UROD","downstream_event_id":846,"downstream_event":"Accumulation, Highly carboxylated porphyrins"},{"relation":543,"upstream_event_id":846,"upstream_event":"Accumulation, Highly carboxylated porphyrins","downstream_event_id":369,"downstream_event":"Uroporphyria"}]}