CHEBI:18357 CHEBI (R)-noradrenaline PR:000001186 PR alpha-2A adrenergic receptor PR:P01101 PR proto-oncogene c-Fos (mouse) D007987 MESH Gonadotropin Releasing Hormone CHEBI:81568 CHEBI Luteinizing hormone GO:0060473 GO cortical granule GO:0060387 GO fertilization envelope D005298 MESH fertility GO:0051380 GO norepinephrine binding GO:0023052 GO signaling GO:0046879 GO hormone secretion GO:0033684 GO regulation of luteinizing hormone secretion MP:0001928 MP abnormal ovulation GO:0046903 GO secretion GO:0035037 GO sperm entry MP:0004023 MP abnormal chromosome number MP:0001921 MP reduced fertility 2 WIKI decreased 5 WIKI delayed 4 WIKI abnormal 1 WIKI increased Decreased, Binding of NE to NE receptors on GnRH neurons Decreased, Binding of NE to NE receptors on GnRH neurons Cellular CL:0011111 CL gonadotropin releasing neuron AOPWiki 2016-11-29T18:41:27 2017-09-16T10:16:28 Inhibition, Antgonism of NE receptor Inhibition, Antgonism of NE receptor Molecular AOPWiki 2016-11-29T18:41:27 2016-12-03T16:37:52 Decreased, GnRH cfos activity Decreased, GnRH cfos activity Molecular CL:0000437 CL gonadtroph AOPWiki 2016-11-29T18:41:25 2017-09-16T10:15:34 Decreased, GnRH pulsatility/release Decreased, GnRH pulsatility/release Cellular CL:0000437 CL gonadtroph AOPWiki 2016-11-29T18:41:25 2017-09-16T10:15:34 Decreased, LH Surge Decreased, LH Surge Cellular CL:0000437 CL gonadtroph AOPWiki 2016-11-29T18:41:25 2017-09-16T10:15:34 Delayed, Ovulation Delayed, Ovulation Individual AOPWiki 2016-11-29T18:41:25 2016-12-03T16:37:50 Decreased, Cortical granule release/distribution upon fertilization Decreased, Cortical granule release/distribution upon fertilization Cellular CL:0000023 CL oocyte AOPWiki 2016-11-29T18:41:25 2017-09-16T10:15:34 Altered, Formation of cortical envelope Altered, Formation of cortical envelope Cellular CL:0000023 CL oocyte AOPWiki 2016-11-29T18:41:25 2017-09-16T10:15:35 Abnormal, Sperm penetration (polyspermy) Abnormal, Sperm penetration (polyspermy) Cellular CL:0000023 CL oocyte AOPWiki 2016-11-29T18:41:25 2017-09-16T10:15:35 Altered, Chromosome number (polyploid) zygote Altered, Chromosome number (polyploid) zygote Cellular CL:0000365 CL animal zygote AOPWiki 2016-11-29T18:41:25 2017-09-16T10:15:35 Decreased, Decreased fecundity Decreased, Decreased fecundity Individual AOPWiki 2016-11-29T18:41:25 2016-12-03T16:37:50 Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation α-noradrenergic- reduced fecundity Brendan Ferreri-Hanberry BY-SA 1.29 1.0 AOPWiki 2016-11-29T18:41:16 2023-09-25T16:26:51