{"id":126,"title":"Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation","short_name":"α-noradrenergic- reduced fecundity","created_at":"2016-11-29T18:41:16.000-05:00","updated_at":"2023-09-25T16:26:51.000-04:00","corresponding_author":{"id":17712,"created_at":"2023-09-11T18:10:58.000-04:00","updated_at":"2023-09-11T18:10:58.000-04:00","subscribed":true,"novice":null},"aop_stressors":[],"aop_mies":[{"event_id":849,"event":"Inhibition, Antgonism of NE receptor","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":848,"event":"Decreased, Binding of NE to NE receptors on GnRH neurons","event_type":"KeyEvent"},{"event_id":529,"event":"Decreased, GnRH cfos activity","event_type":"KeyEvent"},{"event_id":530,"event":"Decreased, GnRH pulsatility/release","event_type":"KeyEvent"},{"event_id":531,"event":"Decreased, LH Surge","event_type":"KeyEvent"},{"event_id":532,"event":"Delayed, Ovulation","event_type":"KeyEvent"},{"event_id":533,"event":"Decreased, Cortical granule release/distribution upon fertilization","event_type":"KeyEvent"},{"event_id":534,"event":"Altered, Formation of cortical envelope","event_type":"KeyEvent"},{"event_id":535,"event":"Abnormal, Sperm penetration (polyspermy)","event_type":"KeyEvent"},{"event_id":536,"event":"Altered, Chromosome number (polyploid) zygote","event_type":"KeyEvent"}],"aop_aos":[{"event_id":527,"event":"Decreased, Decreased fecundity ","event_type":"AdverseOutcome"}],"relationships":[]}