{"id":122,"title":"Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation","short_name":"Prolyl hydroxylase inhibition ","created_at":"2016-11-29T18:41:16.000-05:00","updated_at":"2023-09-25T16:26:51.000-04:00","corresponding_author":{"id":17717,"created_at":"2023-09-11T18:10:59.000-04:00","updated_at":"2023-09-12T12:20:02.000-04:00","subscribed":true,"novice":null},"aop_stressors":[],"aop_mies":[{"event_id":798,"event":"Inhibition, Prolyl hydroxylases","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":799,"event":"Increased, HIF-1 heterodimer","event_type":"KeyEvent"},{"event_id":800,"event":"Decreased, Aromatase (Cyp19a1) mRNA","event_type":"KeyEvent"},{"event_id":3,"event":"Reduction, 17beta-estradiol synthesis by ovarian granulosa cells","event_type":"KeyEvent"},{"event_id":219,"event":"Reduction, Plasma 17beta-estradiol concentrations","event_type":"KeyEvent"},{"event_id":285,"event":"Reduction, Vitellogenin synthesis in liver","event_type":"KeyEvent"},{"event_id":221,"event":"Reduction, Plasma vitellogenin concentrations","event_type":"KeyEvent"},{"event_id":309,"event":"Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development","event_type":"KeyEvent"}],"aop_aos":[{"event_id":78,"event":"Reduction, Cumulative fecundity and spawning","event_type":"AdverseOutcome"},{"event_id":360,"event":"Decrease, Population growth rate","event_type":"AdverseOutcome"}],"relationships":[{"relation":468,"upstream_event_id":798,"upstream_event":"Inhibition, Prolyl hydroxylases","downstream_event_id":799,"downstream_event":"Increased, HIF-1 heterodimer"},{"relation":469,"upstream_event_id":799,"upstream_event":"Increased, HIF-1 heterodimer","downstream_event_id":800,"downstream_event":"Decreased, Aromatase (Cyp19a1) mRNA"},{"relation":470,"upstream_event_id":800,"upstream_event":"Decreased, Aromatase (Cyp19a1) mRNA","downstream_event_id":3,"downstream_event":"Reduction, 17beta-estradiol synthesis by ovarian granulosa cells"},{"relation":471,"upstream_event_id":3,"upstream_event":"Reduction, 17beta-estradiol synthesis by ovarian granulosa cells","downstream_event_id":219,"downstream_event":"Reduction, Plasma 17beta-estradiol concentrations"},{"relation":472,"upstream_event_id":219,"upstream_event":"Reduction, Plasma 17beta-estradiol concentrations","downstream_event_id":285,"downstream_event":"Reduction, Vitellogenin synthesis in liver"},{"relation":473,"upstream_event_id":285,"upstream_event":"Reduction, Vitellogenin synthesis in liver","downstream_event_id":221,"downstream_event":"Reduction, Plasma vitellogenin concentrations"},{"relation":474,"upstream_event_id":221,"upstream_event":"Reduction, Plasma vitellogenin concentrations","downstream_event_id":309,"downstream_event":"Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development"},{"relation":475,"upstream_event_id":309,"upstream_event":"Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development","downstream_event_id":78,"downstream_event":"Reduction, Cumulative fecundity and spawning"},{"relation":476,"upstream_event_id":78,"upstream_event":"Reduction, Cumulative fecundity and spawning","downstream_event_id":360,"downstream_event":"Decrease, Population growth rate"}]}