PR:P31214 PR 3-oxo-5-alpha-steroid 4-dehydrogenase 2 (rat) CHEBI:81568 CHEBI Luteinizing hormone CL:0000178 CL Leydig cell CHEBI:17347 CHEBI testosterone GO:0003824 GO catalytic activity MP:0001152 MP Leydig cell hyperplasia GO:0061370 GO testosterone biosynthetic process MP:0002006 MP neoplasm 2 WIKI decreased 1 WIKI increased Finasteride 2016-11-29T18:42:27 2016-11-29T18:42:27 10116 NCBI Rattus norvegicus 10090 NCBI Mus musculus Inhibition, 5α-reductase activity Cellular AOPWiki 2016-11-29T18:41:27 2016-12-03T16:37:51 Increased, Leutinizing hormone (LH) Tissue UBERON:0001977 UBERON serum AOPWiki 2016-11-29T18:41:27 2017-09-16T10:16:20 Increase, Hyperplasia (Leydig cells) Cellular CL:0000178 CL Leydig cell AOPWiki 2016-11-29T18:41:26 2017-09-16T10:16:09 Decrease, Bioactivation of testosterone Tissue UBERON:0000178 UBERON blood AOPWiki 2016-11-29T18:41:27 2017-09-16T10:16:20 Increase, Leydig cell tumors Cellular CL:0000178 CL Leydig cell AOPWiki 2016-11-29T18:41:26 2017-09-16T10:16:09 #<Reference::ActiveRecord_Associations_CollectionProxy:0x00007b430ae62738> AOPWiki 2016-11-29T18:41:35 2016-12-03T16:38:00 #<Reference::ActiveRecord_Associations_CollectionProxy:0x00007b430ae97488> AOPWiki 2016-11-29T18:41:35 2016-12-03T16:38:00 #<Reference::ActiveRecord_Associations_CollectionProxy:0x00007b430aebcd00> AOPWiki 2016-11-29T18:41:35 2016-12-03T16:38:00 #<Reference::ActiveRecord_Associations_CollectionProxy:0x00007b430aee9ff8> AOPWiki 2016-11-29T18:41:35 2016-12-03T16:37:59 5α-reductase- Leydig tumor Arthur Author <p>Cancer AOP Workgroup. National Health and Environmental Effects Research Laboratory, Office of Research and Development, Integrated Systems Toxicology Division, US Environmental Protection Agency, Research Triangle Park, NC. Corresponding author for wiki entry (wood.charles@epa.gov)</p> BY-SA 1.29 1.0 <p>This putative adverse outcome pathway (AOP) outlines potential key events leading to a tumor outcome in standard carcinogenicity models. This information is based largely on modes of action described previously in cited literature sources and is intended as a resource template for AOP development and data organization. Presentation in this Wiki does not indicate EPA acceptance of a particular pathway for a given reference agent, only that the information has been proposed in some manner. In addition, this putative AOP relates to the model species indicated and does not directly address issues of human relevance.</p> adjacent Not Specified Not Specified adjacent Not Specified Not Specified adjacent Not Specified Not Specified adjacent Not Specified Not Specified Not Specified Male Not Specified Not Specified <p>Cook, J. C., Klinefelter, G. R., Hardisty, J. F., Sharpe, R. M., &amp; Foster, P. M. (1999). Rodent Leydig cell tumorigenesis: a review of the physiology, pathology, mechanisms, and relevance to humans. Crit Rev Toxicol, 29(2), 169-261. doi: 10.1080/10408449991349203</p> AOPWiki 2016-11-29T18:41:16 2023-09-25T16:26:51