{"id":120,"title":"Inhibition of 5α-reductase leading to Leydig cell tumors (in rat)","short_name":"5α-reductase- Leydig tumor","created_at":"2016-11-29T18:41:16.000-05:00","updated_at":"2023-09-25T16:26:51.000-04:00","corresponding_author":{"id":17713,"created_at":"2023-09-11T18:10:58.000-04:00","updated_at":"2023-12-20T10:05:07.000-05:00","subscribed":true,"novice":null},"aop_stressors":[],"aop_mies":[{"event_id":790,"event":"Inhibition, 5α-reductase activity","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":791,"event":"Increased, Leutinizing hormone (LH)","event_type":"KeyEvent"},{"event_id":744,"event":"Increase, Hyperplasia (Leydig cells)","event_type":"KeyEvent"},{"event_id":792,"event":"Decrease, Bioactivation of testosterone","event_type":"KeyEvent"}],"aop_aos":[{"event_id":745,"event":"Increase, Leydig cell tumors","event_type":"AdverseOutcome"}],"relationships":[{"relation":460,"upstream_event_id":790,"upstream_event":"Inhibition, 5α-reductase activity","downstream_event_id":792,"downstream_event":"Decrease, Bioactivation of testosterone"},{"relation":461,"upstream_event_id":792,"upstream_event":"Decrease, Bioactivation of testosterone","downstream_event_id":791,"downstream_event":"Increased, Leutinizing hormone (LH)"},{"relation":462,"upstream_event_id":791,"upstream_event":"Increased, Leutinizing hormone (LH)","downstream_event_id":744,"downstream_event":"Increase, Hyperplasia (Leydig cells)"},{"relation":463,"upstream_event_id":744,"upstream_event":"Increase, Hyperplasia (Leydig cells)","downstream_event_id":745,"downstream_event":"Increase, Leydig cell tumors"}]}