{"id":118,"title":"Chronic cytotoxicity leading to hepatocellular adenomas and carcinomas (in mouse and rat)","short_name":"Chronic cytotoxicity- HCC","created_at":"2016-11-29T18:41:16.000-05:00","updated_at":"2023-09-25T16:26:50.000-04:00","corresponding_author":{"id":17711,"created_at":"2023-09-11T18:10:58.000-04:00","updated_at":"2023-09-11T18:10:58.000-04:00","subscribed":true,"novice":null},"aop_stressors":[],"aop_mies":[{"event_id":786,"event":"Increase, Cytotoxicity (hepatocytes)","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":787,"event":"Increase, Regenerative cell proliferation (hepatocytes)","event_type":"KeyEvent"},{"event_id":774,"event":"Increase, Preneoplastic foci (hepatocytes)","event_type":"KeyEvent"}],"aop_aos":[{"event_id":719,"event":"Increase, hepatocellular adenomas and carcinomas","event_type":"AdverseOutcome"}],"relationships":[{"relation":451,"upstream_event_id":786,"upstream_event":"Increase, Cytotoxicity (hepatocytes)","downstream_event_id":787,"downstream_event":"Increase, Regenerative cell proliferation (hepatocytes)"},{"relation":452,"upstream_event_id":787,"upstream_event":"Increase, Regenerative cell proliferation (hepatocytes)","downstream_event_id":774,"downstream_event":"Increase, Preneoplastic foci (hepatocytes)"},{"relation":453,"upstream_event_id":774,"upstream_event":"Increase, Preneoplastic foci (hepatocytes)","downstream_event_id":719,"downstream_event":"Increase, hepatocellular adenomas and carcinomas"}]}