{"id":117,"title":"Androgen receptor activation leading to hepatocellular adenomas and carcinomas (in mouse and rat)","short_name":"AR- HCC","created_at":"2016-11-29T18:41:16.000-05:00","updated_at":"2023-09-25T16:26:50.000-04:00","corresponding_author":{"id":17710,"created_at":"2023-09-11T18:10:58.000-04:00","updated_at":"2023-09-11T18:10:58.000-04:00","subscribed":true,"novice":null},"aop_stressors":[],"aop_mies":[{"event_id":785,"event":"Activation, Androgen receptor","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":716,"event":"Increase, cell proliferation (hepatocytes)","event_type":"KeyEvent"},{"event_id":774,"event":"Increase, Preneoplastic foci (hepatocytes)","event_type":"KeyEvent"}],"aop_aos":[{"event_id":719,"event":"Increase, hepatocellular adenomas and carcinomas","event_type":"AdverseOutcome"}],"relationships":[{"relation":448,"upstream_event_id":785,"upstream_event":"Activation, Androgen receptor","downstream_event_id":716,"downstream_event":"Increase, cell proliferation (hepatocytes)"},{"relation":449,"upstream_event_id":716,"upstream_event":"Increase, cell proliferation (hepatocytes)","downstream_event_id":774,"downstream_event":"Increase, Preneoplastic foci (hepatocytes)"},{"relation":450,"upstream_event_id":774,"upstream_event":"Increase, Preneoplastic foci (hepatocytes)","downstream_event_id":719,"downstream_event":"Increase, hepatocellular adenomas and carcinomas"}]}