335104-84-2 IUQAXCIUEPFPSF-UHFFFAOYSA-N IUQAXCIUEPFPSF-UHFFFAOYSA-N Tembotrione DTXSID5047037 PR:P32755 PR 4-hydroxyphenylpyruvate dioxygenase (rat) CHEBI:18186 CHEBI tyrosine CL:0000575 CL corneal epithelial cell D010212 MESH papilloma D002277 MESH Carcinoma GO:0003868 GO 4-hydroxyphenylpyruvate dioxygenase activity GO:0008219 GO cell death GO:0006954 GO inflammatory response GO:0008283 GO cell proliferation 2 WIKI decreased 1 WIKI increased Nitisinone 2016-11-29T18:42:27 2016-11-29T18:42:27 Tembotrione 2016-11-29T18:42:27 2016-11-29T18:42:27 10116 NCBI Rattus norvegicus Inhibition, 4-hydroxyphenyl-pyruvate dioxygenase (HPPD) enzyme Molecular <p>This key event commonly operates through HPPD inhibitors. </p> AOPWiki 2016-11-29T18:41:26 2016-12-03T16:37:51 Increased, Plasma tyrosine Tissue UBERON:0001969 UBERON blood plasma AOPWiki 2016-11-29T18:41:26 2017-09-16T10:16:13 Increase, Cytotoxicity (corneal cells) Cellular CL:0000575 CL corneal epithelial cell AOPWiki 2016-11-29T18:41:26 2017-09-16T10:16:12 Increase, Inflammation (corneal cells) Cellular CL:0000575 CL corneal epithelial cell AOPWiki 2016-11-29T18:41:27 2017-09-16T10:16:12 Increase, Regenerative cell proliferation (corneal cells) Cellular CL:0000575 CL corneal epithelial cell AOPWiki 2016-11-29T18:41:27 2017-09-16T10:16:12 Increase, Papillomas/carcinomas (squamous cells) Cellular CL:0000076 CL squamous epithelial cell AOPWiki 2016-11-29T18:41:27 2017-09-16T10:16:12 #<Reference::ActiveRecord_Associations_CollectionProxy:0x00007b430ac56020> AOPWiki 2016-11-29T18:41:35 2016-12-03T16:38:00 #<Reference::ActiveRecord_Associations_CollectionProxy:0x00007b430ac774f0> AOPWiki 2016-11-29T18:41:35 2016-12-03T16:38:00 #<Reference::ActiveRecord_Associations_CollectionProxy:0x00007b430ac9c9d0> AOPWiki 2016-11-29T18:41:35 2016-12-03T16:38:00 #<Reference::ActiveRecord_Associations_CollectionProxy:0x00007b430acd5b18> AOPWiki 2016-11-29T18:41:35 2016-12-03T16:38:00 #<Reference::ActiveRecord_Associations_CollectionProxy:0x00007b430acef248> AOPWiki 2016-11-29T18:41:35 2016-12-03T16:38:00 HPPD- corneal papilloma/carcinoma Arthur Author <p>Cancer AOP group. National Health and Environmental Effects Research Laboratory, Office of Research and Development, Integrated Systems Toxicology Division, US Environmental Protection Agency, Research Triangle Park, NC. Corresponding author for wiki entry (wood.charles@epa.gov)</p> BY-SA 1.29 1.0 <p>This putative adverse outcome pathway (AOP) outlines potential key events leading to a tumor outcome in standard carcinogenicity models. This information is based largely on modes of action described previously in cited literature sources and is intended as a resource template for AOP development and data organization. Presentation in this Wiki does not indicate EPA acceptance of a particular pathway for a given reference agent, only that the information has been proposed in some manner. In addition, this putative AOP relates to the model species indicated and does not directly address issues of human relevance.</p> adjacent Not Specified Not Specified adjacent Not Specified Not Specified adjacent Not Specified Not Specified adjacent Not Specified Not Specified adjacent Not Specified Not Specified Not Specified Male Not Specified Female Not Specified <p>Lewis, R. W., &amp; Botham, J. W. (2013). A review of the mode of toxicity and relevance to humans of the triketone herbicide 2-(4-methylsulfonyl-2-nitrobenzoyl)-1,3-cyclohexanedione. Crit Rev Toxicol, 43(3), 185-199. doi: 10.3109/10408444.2013.764279</p> <p>U.S. Environmental Protection Agency. (September 7, 2007). Tembotrione Human Health Risk Assessment.: Retrieved from <a class="external free" href="http://www.regulations.gov/" rel="nofollow" target="_blank">http://www.regulations.gov/</a>.</p> AOPWiki 2016-11-29T18:41:16 2023-09-25T16:26:50