{"id":114,"title":"HPPD inhibition leading to corneal papillomas and carcinomas (in rat)","short_name":"HPPD- corneal papilloma/carcinoma","created_at":"2016-11-29T18:41:16.000-05:00","updated_at":"2023-09-25T16:26:50.000-04:00","corresponding_author":{"id":17713,"created_at":"2023-09-11T18:10:58.000-04:00","updated_at":"2023-12-20T10:05:07.000-05:00","subscribed":true,"novice":null},"aop_stressors":[],"aop_mies":[{"event_id":766,"event":"Inhibition, 4-hydroxyphenyl-pyruvate dioxygenase (HPPD) enzyme","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":775,"event":"Increased, Plasma tyrosine","event_type":"KeyEvent"},{"event_id":776,"event":"Increase, Cytotoxicity (corneal cells)","event_type":"KeyEvent"},{"event_id":777,"event":"Increase, Inflammation (corneal cells)","event_type":"KeyEvent"},{"event_id":778,"event":"Increase, Regenerative cell proliferation (corneal cells)","event_type":"KeyEvent"}],"aop_aos":[{"event_id":779,"event":"Increase, Papillomas/carcinomas (squamous cells)","event_type":"AdverseOutcome"}],"relationships":[{"relation":436,"upstream_event_id":766,"upstream_event":"Inhibition, 4-hydroxyphenyl-pyruvate dioxygenase (HPPD) enzyme","downstream_event_id":775,"downstream_event":"Increased, Plasma tyrosine"},{"relation":437,"upstream_event_id":775,"upstream_event":"Increased, Plasma tyrosine","downstream_event_id":776,"downstream_event":"Increase, Cytotoxicity (corneal cells)"},{"relation":438,"upstream_event_id":776,"upstream_event":"Increase, Cytotoxicity (corneal cells)","downstream_event_id":777,"downstream_event":"Increase, Inflammation (corneal cells)"},{"relation":439,"upstream_event_id":777,"upstream_event":"Increase, Inflammation (corneal cells)","downstream_event_id":778,"downstream_event":"Increase, Regenerative cell proliferation (corneal cells)"},{"relation":440,"upstream_event_id":778,"upstream_event":"Increase, Regenerative cell proliferation (corneal cells)","downstream_event_id":779,"downstream_event":"Increase, Papillomas/carcinomas (squamous cells)"}]}