{"id":110,"title":"Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse)","short_name":"Iodide pump inhibition- follicular adenoma/carcinoma","created_at":"2016-11-29T18:41:16.000-05:00","updated_at":"2023-09-25T16:26:50.000-04:00","corresponding_author":{"id":17717,"created_at":"2023-09-11T18:10:59.000-04:00","updated_at":"2023-09-12T12:20:02.000-04:00","subscribed":true,"novice":null},"aop_stressors":[],"aop_mies":[{"event_id":424,"event":"Inhibition, Na+/I- symporter (NIS)","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":277,"event":"Thyroid hormone synthesis, Decreased","event_type":"KeyEvent"},{"event_id":281,"event":" Thyroxine (T4) in serum, Decreased","event_type":"KeyEvent"},{"event_id":1023,"event":"Increased, Thyroid-stimulating hormone (TSH)","event_type":"KeyEvent"},{"event_id":739,"event":"Increase, Hypertrophy and proliferation (follicular cell)","event_type":"KeyEvent"},{"event_id":740,"event":"Increase, Hyperplasia (follicular cells)","event_type":"KeyEvent"}],"aop_aos":[{"event_id":741,"event":"Increase, Adenomas/carcinomas (follicular cell)","event_type":"AdverseOutcome"}],"relationships":[{"relation":2839,"upstream_event_id":424,"upstream_event":"Inhibition, Na+/I- symporter (NIS)","downstream_event_id":277,"downstream_event":"Thyroid hormone synthesis, Decreased"},{"relation":2739,"upstream_event_id":277,"upstream_event":"Thyroid hormone synthesis, Decreased","downstream_event_id":281,"downstream_event":" Thyroxine (T4) in serum, Decreased"},{"relation":2744,"upstream_event_id":281,"upstream_event":" Thyroxine (T4) in serum, Decreased","downstream_event_id":1023,"downstream_event":"Increased, Thyroid-stimulating hormone (TSH)"},{"relation":2745,"upstream_event_id":1023,"upstream_event":"Increased, Thyroid-stimulating hormone (TSH)","downstream_event_id":739,"downstream_event":"Increase, Hypertrophy and proliferation (follicular cell)"},{"relation":408,"upstream_event_id":739,"upstream_event":"Increase, Hypertrophy and proliferation (follicular cell)","downstream_event_id":740,"downstream_event":"Increase, Hyperplasia (follicular cells)"},{"relation":409,"upstream_event_id":740,"upstream_event":"Increase, Hyperplasia (follicular cells)","downstream_event_id":741,"downstream_event":"Increase, Adenomas/carcinomas (follicular cell)"}]}