CL:0002328 CL bronchial epithelial cell D000236 MESH Adenoma D002277 MESH Carcinoma CL:0000158 CL Clara cell GO:0008219 GO cell death GO:0050673 GO epithelial cell proliferation D006965 MESH hyperplasia 1 WIKI increased 10090 NCBI Mus musculus Increase, Necrosis (terminal bronchiolar cells) Cellular CL:0002328 CL bronchial epithelial cell AOPWiki 2016-11-29T18:41:26 2017-09-16T10:16:05 Increase, Regenerative cell proliferation (terminal bronchiolar epithelial cells) Cellular AOPWiki 2016-11-29T18:41:26 2016-12-03T16:37:51 Increase, Hyperplasia (terminal bronchiolar cells) Cellular UBERON:0001958 UBERON terminal bronchiole epithelium CL:0002328 CL bronchial epithelial cell AOPWiki 2016-11-29T18:41:26 2017-09-16T10:16:06 Increase, Adenomas/carcinomas (bronchioloalveolar) Tissue UBERON:0002048 UBERON lung AOPWiki 2016-11-29T18:41:26 2017-09-16T10:16:06 Increase, Cytotoxicity (club cells) Cellular <p>This key event can be associated with Cyp2f2 bioactivation. </p> CL:0000158 CL Clara cell AOPWiki 2016-11-29T18:41:26 2017-09-16T10:16:06 #<Reference::ActiveRecord_Associations_CollectionProxy:0x00007b42e9a53528> AOPWiki 2016-11-29T18:41:35 2016-12-03T16:37:59 #<Reference::ActiveRecord_Associations_CollectionProxy:0x00007b42e9a6ed78> AOPWiki 2016-11-29T18:41:35 2016-12-03T16:37:59 #<Reference::ActiveRecord_Associations_CollectionProxy:0x00007b42e9a8ae10> AOPWiki 2016-11-29T18:41:35 2016-12-03T16:37:59 #<Reference::ActiveRecord_Associations_CollectionProxy:0x00007b42e9aaae18> AOPWiki 2016-11-29T18:41:35 2016-12-03T16:38:00 Cytotoxicity- bronchiolar adenoma/carcinoma Agnes Aggy <p>Cancer AOP group. National Health and Environmental Effects Research Laboratory, Office of Research and Development, Integrated Systems Toxicology Division, US Environmental Protection Agency, Research Triangle Park, NC. Corresponding author for wiki entry (wood.charles@epa.gov)</p> BY-SA 1.29 1.0 <p>This putative adverse outcome pathway (AOP) outlines potential key events leading to a tumor outcome in standard carcinogenicity models. This information is based largely on modes of action described previously in cited literature sources and is intended as a resource template for AOP development and data organization. Presentation in this Wiki does not indicate EPA acceptance of a particular pathway for a given reference agent, only that the information has been proposed in some manner. In addition, this putative AOP relates to the model species indicated and does not directly address issues of human relevance.</p> adjacent Not Specified Not Specified adjacent Not Specified Not Specified adjacent Not Specified Not Specified adjacent Not Specified Not Specified Not Specified Male Not Specified Female Not Specified AOPWiki 2016-11-29T18:41:16 2023-09-25T16:26:50