{"id":109,"title":"Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse)","short_name":"Cytotoxicity- bronchiolar adenoma/carcinoma","created_at":"2016-11-29T18:41:16.000-05:00","updated_at":"2023-09-25T16:26:50.000-04:00","corresponding_author":{"id":17716,"created_at":"2023-09-11T18:10:59.000-04:00","updated_at":"2023-11-28T16:27:24.000-05:00","subscribed":true,"novice":null},"aop_stressors":[],"aop_mies":[{"event_id":770,"event":"Increase, Cytotoxicity (club cells)","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":733,"event":"Increase, Necrosis (terminal bronchiolar cells)","event_type":"KeyEvent"},{"event_id":734,"event":"Increase, Regenerative cell proliferation (terminal bronchiolar epithelial cells)","event_type":"KeyEvent"},{"event_id":735,"event":"Increase, Hyperplasia (terminal bronchiolar cells)","event_type":"KeyEvent"}],"aop_aos":[{"event_id":736,"event":"Increase, Adenomas/carcinomas (bronchioloalveolar)","event_type":"AdverseOutcome"}],"relationships":[{"relation":397,"upstream_event_id":733,"upstream_event":"Increase, Necrosis (terminal bronchiolar cells)","downstream_event_id":734,"downstream_event":"Increase, Regenerative cell proliferation (terminal bronchiolar epithelial cells)"},{"relation":398,"upstream_event_id":734,"upstream_event":"Increase, Regenerative cell proliferation (terminal bronchiolar epithelial cells)","downstream_event_id":735,"downstream_event":"Increase, Hyperplasia (terminal bronchiolar cells)"},{"relation":399,"upstream_event_id":735,"upstream_event":"Increase, Hyperplasia (terminal bronchiolar cells)","downstream_event_id":736,"downstream_event":"Increase, Adenomas/carcinomas (bronchioloalveolar)"},{"relation":429,"upstream_event_id":770,"upstream_event":"Increase, Cytotoxicity (club cells)","downstream_event_id":733,"downstream_event":"Increase, Necrosis (terminal bronchiolar cells)"}]}