{"id":108,"title":"Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat)","short_name":"PDK inhibition- HCC","created_at":"2016-11-29T18:41:16.000-05:00","updated_at":"2023-09-25T16:26:50.000-04:00","corresponding_author":{"id":17713,"created_at":"2023-09-11T18:10:58.000-04:00","updated_at":"2023-12-20T10:05:07.000-05:00","subscribed":true,"novice":null},"aop_stressors":[],"aop_mies":[{"event_id":724,"event":"Inhibition, Pyruvate dehydrogenase kinase (PDK) enzyme","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":768,"event":"Increase, Cytotoxicity","event_type":"KeyEvent"},{"event_id":209,"event":"Peptide Oxidation","event_type":"KeyEvent"},{"event_id":726,"event":"Increased, Induction of pyruvate dehydrogenase (PDH)","event_type":"KeyEvent"},{"event_id":769,"event":"Increase, Oxidative metabolism","event_type":"KeyEvent"}],"aop_aos":[{"event_id":719,"event":"Increase, hepatocellular adenomas and carcinomas","event_type":"AdverseOutcome"}],"relationships":[{"relation":394,"upstream_event_id":724,"upstream_event":"Inhibition, Pyruvate dehydrogenase kinase (PDK) enzyme","downstream_event_id":726,"downstream_event":"Increased, Induction of pyruvate dehydrogenase (PDH)"},{"relation":425,"upstream_event_id":726,"upstream_event":"Increased, Induction of pyruvate dehydrogenase (PDH)","downstream_event_id":769,"downstream_event":"Increase, Oxidative metabolism"},{"relation":426,"upstream_event_id":769,"upstream_event":"Increase, Oxidative metabolism","downstream_event_id":209,"downstream_event":"Peptide Oxidation"},{"relation":427,"upstream_event_id":209,"upstream_event":"Peptide Oxidation","downstream_event_id":768,"downstream_event":"Increase, Cytotoxicity"},{"relation":428,"upstream_event_id":768,"upstream_event":"Increase, Cytotoxicity","downstream_event_id":719,"downstream_event":"Increase, hepatocellular adenomas and carcinomas"}]}