{"id":105,"title":"Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat)","short_name":"α2u-globulin- renal adenomas/carcinomas","created_at":"2016-11-29T18:41:16.000-05:00","updated_at":"2023-09-25T16:26:50.000-04:00","corresponding_author":{"id":17710,"created_at":"2023-09-11T18:10:58.000-04:00","updated_at":"2023-09-11T18:10:58.000-04:00","subscribed":true,"novice":null},"aop_stressors":[],"aop_mies":[{"event_id":714,"event":"Increased, Binding of chemicals to 2u (serum)","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":708,"event":"Increased, Accumulation of alpha2u microglobulin (proximal tubular epithelium)","event_type":"KeyEvent"},{"event_id":709,"event":"Increase, Cytotoxicity (renal tubular cell)","event_type":"KeyEvent"},{"event_id":710,"event":"Increase, Regenerative cell proliferation (tubular epithelial cells)","event_type":"KeyEvent"},{"event_id":767,"event":"Increase, Hyperplasia (renal tubular cells)","event_type":"KeyEvent"}],"aop_aos":[{"event_id":713,"event":"Increase, Adenomas/carcinomas (renal tubular)","event_type":"AdverseOutcome"}],"relationships":[{"relation":389,"upstream_event_id":714,"upstream_event":"Increased, Binding of chemicals to 2u (serum)","downstream_event_id":708,"downstream_event":"Increased, Accumulation of alpha2u microglobulin (proximal tubular epithelium)"},{"relation":390,"upstream_event_id":708,"upstream_event":"Increased, Accumulation of alpha2u microglobulin (proximal tubular epithelium)","downstream_event_id":709,"downstream_event":"Increase, Cytotoxicity (renal tubular cell)"},{"relation":391,"upstream_event_id":709,"upstream_event":"Increase, Cytotoxicity (renal tubular cell)","downstream_event_id":710,"downstream_event":"Increase, Regenerative cell proliferation (tubular epithelial cells)"},{"relation":423,"upstream_event_id":710,"upstream_event":"Increase, Regenerative cell proliferation (tubular epithelial cells)","downstream_event_id":767,"downstream_event":"Increase, Hyperplasia (renal tubular cells)"},{"relation":424,"upstream_event_id":767,"upstream_event":"Increase, Hyperplasia (renal tubular cells)","downstream_event_id":713,"downstream_event":"Increase, Adenomas/carcinomas (renal tubular)"}]}