{"id":10,"title":"Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain","short_name":"Blocking iGABA receptor ion channel leading to seizures","created_at":"2016-11-29T18:41:16.000-05:00","updated_at":"2023-09-25T16:26:44.000-04:00","corresponding_author":{"id":17711,"created_at":"2023-09-11T18:10:58.000-04:00","updated_at":"2023-09-11T18:10:58.000-04:00","subscribed":true,"novice":null},"aop_stressors":[{"stressor_id":110,"stressor_name":"Picrotoxin"},{"stressor_id":112,"stressor_name":"Lindane"},{"stressor_id":115,"stressor_name":"Dieldrin"},{"stressor_id":344,"stressor_name":"Heptachlor"},{"stressor_id":345,"stressor_name":"Endosulfan"},{"stressor_id":113,"stressor_name":"RDX"},{"stressor_id":111,"stressor_name":"Fipronil"}],"aop_mies":[{"event_id":667,"event":"Binding at picrotoxin site, iGABAR chloride channel","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":64,"event":"Reduction, Ionotropic GABA receptor chloride channel conductance","event_type":"KeyEvent"},{"event_id":669,"event":"Reduction, Neuronal synaptic inhibition","event_type":"KeyEvent"},{"event_id":682,"event":"Generation, Amplified excitatory postsynaptic potential (EPSP)","event_type":"KeyEvent"},{"event_id":616,"event":"Occurrence, A paroxysmal depolarizing shift","event_type":"KeyEvent"}],"aop_aos":[{"event_id":613,"event":"Occurrence, Epileptic seizure","event_type":"AdverseOutcome"}],"relationships":[{"relation":349,"upstream_event_id":667,"upstream_event":"Binding at picrotoxin site, iGABAR chloride channel","downstream_event_id":64,"downstream_event":"Reduction, Ionotropic GABA receptor chloride channel conductance"},{"relation":350,"upstream_event_id":64,"upstream_event":"Reduction, Ionotropic GABA receptor chloride channel conductance","downstream_event_id":669,"downstream_event":"Reduction, Neuronal synaptic inhibition"},{"relation":364,"upstream_event_id":669,"upstream_event":"Reduction, Neuronal synaptic inhibition","downstream_event_id":682,"downstream_event":"Generation, Amplified excitatory postsynaptic potential (EPSP)"},{"relation":610,"upstream_event_id":682,"upstream_event":"Generation, Amplified excitatory postsynaptic potential (EPSP)","downstream_event_id":616,"downstream_event":"Occurrence, A paroxysmal depolarizing shift"},{"relation":351,"upstream_event_id":616,"upstream_event":"Occurrence, A paroxysmal depolarizing shift","downstream_event_id":613,"downstream_event":"Occurrence, Epileptic seizure"}]}